Methotrexate is one of the most effective and commonly used medications in the treatment of rheumatoid arthritis and other forms of inflammatory arthritis, and also may be used to treat lupus, inflammatory myositis, vasculitis, and some forms of childhood arthritis. Therefore, it is not recommended for women of childbearing potential unless there is clear medical evidence that the benefits can be expected to outweigh the considered risks. Dec 18, · Bulatovic M, Heijstek MW, Verkaaik M, van Dijkhuizen EH, Armbrust W, Hoppenreijs EP, Kamphuis S, Kuis W, Egberts TC, Sinnema G, Rademaker CM: High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a. Find patient medical information for Methotrexate Sodium Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Pregnant women with psoriasis or rheumatoid arthritis should not receive methotrexate. Types of cancers it is used for include breast cancer, leukemia, lung. Methotrexate has been reported to cause fetal death and/ or congenital anomalies. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Skip to main content. CONCLUSIONS: Starting on methotrexate 15 mg/ week orally, escalating with 5 mg/ month to 25- 30 mg/ week, or the highest tolerable dose, with a subsequent switch to subcutaneous administration in the case of an insufficient response, seems to be the optimal evidence- based dosing and routing recommendation for methotrexate in RA. Methotrexate elimination is reduced in patients with impaired renal functions, ascites, or pleural effusions. Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of therapy. Methotrexate revizuirea artrite reumatoide dosaggio. Methotrexate given concomitantly with radiotherapy may increase the risk of soft tissue necrosis and osteonecrosis. DESCRIPTION Methotrexate ( formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis.
It is often used in combination with other medications to treat arthritis. Methotrexate ( MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.